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The Red Light District isn't any more unsafe than many other parts of town - but do stick to some simple rules (see below).
Young women in lingerie sit or stand behind red-lit windows or glass doors.
At any time of the day you will find a collection of Japanese tourists with cameras, Amsterdammers taking the shortest route to the supermarket, police officers chatting to prostitutes, young women of religious organizations trying to save souls, a few junkies and weirdos, and actually some people looking for paid 'love'.
And usually, it all goes together without much trouble.