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Buffy's death was foreshadowed two full seasons in advance.
You can read the entire baffling thing, along with Whedon's response, here.5.Joss Whedon has described Oz (Seth Green) as "the only character that was really ever based on somebody I knew", the person in question being a very cool college acquaintance who played guitar.6.An alternative first season could have featured Katie Holmes as Buffy and Ryan Reynolds as Xander.Both were offered the roles, with Reynolds reportedly turning it down because he couldn't bear to relive his own grisly high school experience.3.
At this time, Buffy had two years (730 days) left to live.
The line also foreshadows the arrival of Dawn, who is likened to Little Miss Muffet a few times throughout season five.4.