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Among other awards, he has won an Emmy Award, a Golden Globe Award, and has been nominated for an Academy Award. These include George Milton in Of Mice and Men, Lieutenant Dan Taylor in Forrest Gump (for which he was nominated for the Academy Award for Best Supporting Actor), Harry S.
Truman in Truman (for which he won a Golden Globe), Ken Mattingly in Apollo 13, Detective Jimmy Shaker in Ransom, Detective Mac Taylor in the CBS series CSI: NY (2004–13), and George C.
Since then, Steppenwolf has showcased the talents of notable actors such as Joan Allen, Kevin Anderson, Gary Cole, Ethan Hawke, Glenne Headly, John Mahoney, John Malkovich, Laurie Metcalf, Martha Plimpton, Jim True-Frost, and most recently William Petersen.
Sinise honed his acting and directing skills at Steppenwolf, and received a Joseph Jefferson Award for his direction of Lyle Kessler's play Orphans.
That took him from Chicago to New York City, and then to London's West End, where he worked on more than thirty of the company's productions.
In 1983, he earned an Obie Award for his direction, and a year later appeared with John Malkovich in the PBS' American Playhouse production of the play.
In 1988, Sinise directed Miles from Home, a film starring Richard Gere, about two brothers' fight against the foreclosure of the family farm.