These findings do not suggest that insomnia is merely part of a prodrome that occurs in close temporal association with affective disorders, as depression may first appear several years after the initial diagnosis of insomnia. QT prolongation and polymorphous ventricular tachycardia associated with trasodone-amiodarone combination.
This article examines the evidence supporting the efficacy and safety of mood stabilizers in the treatment of comorbid and primary insomnia. Complete heart block following a single dose of trazodone.
Psychiatric disorders and chronic insomnia are often comorbid with each other.
Bridget Banas for her assistance in the preparation of this manuscript.
Complicating the situation, mood stabilizers can disrupt sleep in a variety of different ways depending on a drug’s mechanism of action, dosage level, and timing of administration. The effects of trazodone on sleep in patients treated with stimulant antidepressants. The treatment of comorbid depression and insomnia can be achieved through the use of a sedating antidepressant, a combination of two antidepressants, or a combination of an antidepressant in conjunction with a hypnotic. Psychotropic medication and priapism: a comprehensive review. Zammit is president and CEO of Clinilabs, director of the Sleep Disorders Institute, and clinical associate professor at the Columbia University College of Physicians and Surgeons in New York City. Zammit is a consultant to Boehringer-Ingelheim, sanofi-aventis, Sepracor, and Takeda; receives research support from Forest, Glaxo Smith Kline, Pfizer, sanofi-aventis, Sepracor, Takeda Pharmaceuticals North America, Transcept, and Wyeth; and receives honoraria from Takeda. Possible trazodone potentiation of fluoxetine: a case series. Acknowledgments: The author would like to thank Ms.
The presence of insomnia symptoms in individuals with a current episode of major depressve disprder (MDD) has been shown to approach 80% to 90%. Several longitudinal studies have examined the incidence of psychiatric disorders over periods ranging from 1–40 years following the initial diagnosis of insomnia. Pohl R, Bridges M, Rainey JM Jr, Boudoulas H, Yeragani VK. In every study completed to date, insomnia has been found to be a significant risk factor for the subsequent onset of depression, with a greater incidence of affective disorder found in people with insomnia. Effects of trazodone and desipramine on cardiac rate and rhythm in a patient with preexisting cardiovascular disease.