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Histologically, the ovaries were found to have numerous primordial follicles, some with further development.

When the 10 patients were treated with HMG and HCG, four experienced periods, two noted spotting and the other four did not respond to treatment.

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When 10 patients with primary amenorrhea and normally developed secondary sex characteristics were investigated, total gonadotropins in 24-hour urine collections were either slightly elevated or in the low normal range.

The clinical symptomatology associated with this abnormality differs from that of both pure gonadal dysgenesis and hypogonadotropic eunuchoidism.


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